Nicholas D.P. Cosford: search on Z-Library

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1

Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

Herath, Ananda, Cosford, Nicholas D P

Journal:

Beilstein Journal of Organic Chemistry

Year:

2017

Language:

english

File:

PDF, 475 KB

english, 2017

2

Autophagy in Cancer: Regulation by Small Molecules

Limpert, Allison S., Lambert, Lester J., Bakas, Nicole A., Bata, Nicole, Brun, Sonja N., Shaw, Reuben J., Cosford, Nicholas D.P.

Journal:

Trends in Pharmacological Sciences

Year:

2018

Language:

english

File:

PDF, 3.10 MB

english, 2018

3

Public health professionals' perceptions toward provision of health protection in England: a survey of expectations of Primary Care Trusts and Health Protection Units in the delivery of health protection

Paul A Cosford, Mary O'Mahony, Emma Angell, Graham Bickler, Shirley Crawshaw, Janet Glencross, Stephen S Horsley, Brian McCloskey, Richard Puleston, Nichola Seare, Martin D Tobin

Journal:

BMC Public Health

Year:

2006

Language:

english

File:

PDF, 286 KB

english, 2006

4

AMYLOID PRECURSOR PROTEIN C-TERMINAL CLEAVAGE RESULTING IN THE TOXIC C31 PEPTIDE: STIMULATION OF CLEAVAGE WITH CEREVASTATIN AND INHIBITION AND CELL VIABILITY RESCUE USING SMALL MOLECULES

Poksay, Karen S., Sheffler, Douglas J., Campagna, Jesus, Spilman, Patricia, Mullenix, Michael, Bredesen, Dale E., Cosford, Nicholas D.P., John, Varghese

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 73 KB

english, 2016

5

One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in Situ Hydrolysis of tert- Butyl Esters

Herath, Ananda, Cosford, Nicholas D. P.

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 399 KB

english, 2010

6

3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

Steve F. Poon, Brian W. Eastman, Deborah F. Chapman, Janice Chung, Merryl Cramer, Gregory Holtz, Nicholas D.P. Cosford, Nicholas D. Smith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 268 KB

english, 2004

7

Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

Essa Hu, Peter C. Chua, Lida Tehrani, Johnny Y. Nagasawa, Anthony B. Pinkerton, Blake A. Rowe, Jean-Michel Vernier, John H. Hutchinson, Nicholas D.P. Cosford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 260 KB

english, 2004

8

Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABAA signaling

Aleksandra Klodzinska, Ewa Tatarczyńska, Ewa Chojnacka-Wójcik, Gabriel Nowak, Nicholas D.P Cosford, Andrzej Pilc

Journal:

Neuropharmacology

Year:

2004

Language:

english

File:

PDF, 294 KB

english, 2004

9

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Pinkerton, Anthony B., Sergienko, Eduard, Bravo, Yalda, Dahl, Russell, Ma, Chen-Ting, Sun, Qing, Jackson, Michael R., Cosford, Nicholas D.P., Millán, José Luis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 341 KB

english, 2017

10

2-{2-[3-(Pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

Dehua Huang, Steve F. Poon, Deborah F. Chapman, Janice Chung, Merryl Cramer, Thomas S. Reger, Jeffrey R. Roppe, Lida Tehrani, Nicholas D.P. Cosford, Nicholas D. Smith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

11

A new route to 3-heteroarylindoles

Malcolm M Campbell, Nicholas Cosford, Li Zongli, Malcolm Sainsbury

Journal:

Year:

1987

Language:

english

File:

PDF, 368 KB

english, 1987

12

Selenium nucleophiles for the preparation of antiviral nucleosides

Cosford, Nicholas D. P., Schinazi, Raymond F.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 693 KB

english, 1991

13

One-Step Synthesis of 3-Aryl- and 3,4-Diaryl-(1 H )-Pyrroles Using Tosylmethyl Isocyanide (TOSMIC)

Smith, Nicholas D., Huang, Dehua, Cosford, Nicholas D. P.

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 56 KB

english, 2002

14

( S )-(−)-5-Ethynyl-3-(1-methyl-2-pyrroli- dinyl)pyridine Maleate (SIB-1508Y): A Novel Anti-Parkinsonian Agent with Selectivity for Neuronal Nicotinic Acetylcholine Receptors

Cosford, Nicholas D. P., Bleicher, Leo, Herbaut, Audrey, McCallum, J. Stuart, Vernier, Jean-Michel, Dawson, Heather, Whitten, Jeffrey P., Adams, Pamala, Chavez-Noriega, Laura, Correa, Lucia D., Crona,

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 145 KB

english, 1996

15

Pyrimidine Methyl Anilines: Selective Potentiators for the Metabotropic Glutamate 2 Receptor

Essa Hu, Peter C. Chua, Lida Tehrani, Johnny Y. Nagasawa, Anthony B. Pinkerton, Blake A. Rowe, Jean-Michel Vernier, John H. Hutchinson, Nicholas D. P. Cosford

Journal:

Year:

2005

File:

PDF, 98 KB

2005

16

Expedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology

Brian Eastman, Chixu Chen, Nicholas D. Smith, Steven Poon, Janice Chung, Grace Reyes-Manalo, Nicholas D.P. Cosford, Benito Munoz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 262 KB

english, 2004

17

[3H]-Methoxymethyl-MTEP and [3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

Nicholas D.P Cosford, Jeffrey Roppe, Lida Tehrani, Edwin J Schweiger, T.Jon Seiders, Ashok Chaudary, Sara Rao, Mark A Varney

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 145 KB

english, 2003

18

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity

Nicholas D. Smith, Steve F. Poon, Dehua Huang, Mitchell Green, Christopher King, Lida Tehrani, Jeffrey R. Roppe, Janice Chung, Deborah P. Chapman, Merryl Cramer, Nicholas D.P. Cosford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 265 KB

english, 2004

19

A combination of flow and batch mode processes for the efficient preparation of mGlu 2/3 receptor negative allosteric modulators (NAMs)

Dhanya, Raveendra Panickar, Herath, Ananda, Sheffler, Douglas J., Cosford, Nicholas D.P.

Journal:

Year:

2018

Language:

english

File:

PDF, 587 KB

english, 2018

20

Encyclopedia of Reagents for Organic Synthesis || Iodine-Copper(II) Chloride

Cosford, Nicholas D. P.

Year:

2001

Language:

english

File:

PDF, 46 KB

english, 2001

21

Encyclopedia of Reagents for Organic Synthesis || Copper(II) Chloride

Cosford, Nicholas D. P.

Year:

2001

Language:

english

File:

PDF, 184 KB

english, 2001

22

Amphiphilic suramin dissolves Matrigel, causing an ‘inhibition’ artefact within in vitro angiogenesis assays

Prigozhina, Natalie L., Heisel, Andrew J., Seldeen, Jordan R., Cosford, Nicholas D. P., Price, Jeffrey H.

Journal:

International Journal of Experimental Pathology

Year:

2013

Language:

english

File:

PDF, 463 KB

english, 2013

23

ChemInform Abstract: 2-Aminopyridines via Reaction of Pyridine N-Oxides and Activated Isocyanides.

Vamos, Mitchell, Cosford, Nicholas D. P.

Journal:

Year:

2014

File:

PDF, 25 KB

2014

24

3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists

Lida R. Tehrani, Nicholas D. Smith, Dehua Huang, Steve F. Poon, Jeffrey R. Roppe, Thomas Jon Seiders, Deborah F. Chapman, Janice Chung, Merryl Cramer, Nicholas D.P. Cosford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 150 KB

english, 2005

25

ChemInform Abstract: Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives.

Pagano, Nicholas, Heil, Marintha L., Cosford, Nicholas D. P.

Journal:

Year:

2012

File:

PDF, 36 KB

2012

26

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Cosford, Nicholas D. P., Tehrani, Lida, Roppe, Jeffrey, Schweiger, Edwin, Smith, Nicholas D., Anderson, Jeffrey, Bristow, Linda, Brodkin, Jesse, Jiang, Xiaohui, McDonald, Ian

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 54 KB

english, 2003

27

Encyclopedia of Reagents for Organic Synthesis || Copper(II) Chloride

Cosford, Nicholas D. P.

Year:

2001

Language:

english

File:

PDF, 272 KB

english, 2001

28

Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Yiwei Li, Jun Liang, Tony Siu, Essa Hu, Michael A. Rossi, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, Ronald G. Robinson, Karen Leander, Hans E. Huber, Sachin Mittal, Nicholas Cosford,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 166 KB

english, 2009

29

Rapid Multistep Synthesis of 1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence

Grant, Daniel, Dahl, Russell, Cosford, Nicholas D. P.

Journal:

Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 154 KB

english, 2008

30

Preparation of mono- and diisocyanates in flow from renewable carboxylic acids

Phung Hai, Thien An, De Backer, Laurent Jean Stephane, Cosford, Nicholas D. P., Burkart, Michael D.

Journal:

Organic Process Research & Development

Year:

2020

File:

PDF, 392 KB

2020

31

Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

Kiffer-Moreira, Tina, Yadav, Manisha C, Zhu, Dongxing, Narisawa, Sonoko, Sheen, Campbell, Stec, Boguslaw, Cosford, Nicholas D, Dahl, Russell, Farquharson, Colin, Hoylaerts, Marc F, MacRae, Vicky E, Mi

Journal:

Journal of Bone and Mineral Research

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

32

A Novel Method for the Racemization of 5-Bromonicotine

Bleicher, Leo S., Cosford, Nicholas D. P.

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 42 KB

english, 1999

33

Preface (Nicholas D. P. Cosford)

Cosford, Nicholas

Journal:

Current Drug Targets - CNS & Neurological Disorders

Year:

2003

File:

PDF, 28 KB

2003

34

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM

Douglas J. Sheffler, Cody J. Wenthur, Joshua A. Bruner, Sheridan J.S. Carrington, Paige N. Vinson, Kiran K. Gogi, Anna L. Blobaum, Ryan D. Morrison, Mitchell Vamos, Nicholas D.P. Cosford, Shaun R. Sta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.58 MB

english, 2012

35

2-Aminopyridines via Reaction of Pyridine N -Oxides and Activated Isocyanides

Vamos, Mitchell, Cosford, Nicholas D. P.

Journal:

Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 594 KB

english, 2014

36

Encyclopedia of Reagents for Organic Synthesis || Copper(II) Bromide

Cosford, Nicholas D. P.

Year:

2001

Language:

english

File:

PDF, 135 KB

english, 2001

37

An Automated Process for a Sequential Heterocycle/Multicomponent Reaction: Multistep Continuous Flow Synthesis of 5-(Thiazol-2-yl)-3,4-Dihydropyrimidin-2( 1H )-ones

Pagano, Nicholas, Herath, Ananda, Cosford, Nicholas D. P.

Journal:

Journal of Flow Chemistry

Year:

2012

Language:

english

File:

PDF, 186 KB

english, 2012

38

[Annual Reports in Medicinal Chemistry] Volume 33 || Recent Progress In Antiepileptic Drug Research

Cosford, Nicholas D.P.

Year:

1998

Language:

english

File:

PDF, 748 KB

english, 1998

39

ChemInform Abstract: One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in situ Hydrolysis of tert-Butyl Esters.

Ananda Herath, Nicholas D. P. Cosford

Journal:

Year:

2011

File:

PDF, 38 KB

2011

40

Identification of metabotropic glutamate receptor antagonists using an automated high-throughput screening system

Peter Hodder, Jason Cassaday, Richard Peltier, Kurtis Berry, James Inglese, Bradley Feuston, Chris Culberson, Leo Bleicher, Nicholas D.P Cosford, Chris Bayly, Carla Suto, Mark Varney, Berta Strulovici

Journal:

Analytical Biochemistry

Year:

2003

Language:

english

File:

PDF, 616 KB

english, 2003

41

Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist

Tadimeti S. Rao, Pamala B. Adams, Lucia D. Correa, Emily M. Santori, Aida I. Sacaan, Richard T. Reid, Nicholas D.P. Cosford

Journal:

Year:

2008

Language:

english

File:

PDF, 1.01 MB

english, 2008

42

The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats

Jin, Xinchun, Semenova, Svetlana, Yang, Li, Ardecky, Robert, Sheffler, Douglas J, Dahl, Russell, Conn, P Jeffrey, Cosford, Nicholas DP, Markou, Athina

Journal:

Neuropsychopharmacology

Year:

2010

Language:

english

File:

PDF, 784 KB

english, 2010

43

An Improved Method for the Synthesis of Cationic (.eta.5-Cyclopentadienyl)(.eta.3-allyl)Mo(CO)(NO) Complexes: The Benefit of 1,2-Dimethoxyethane as a Solvent

Cosford, Nicholas D. P., Liebeskind, Lanny S.

Journal:

Organometallics

Year:

1994

Language:

english

File:

PDF, 722 KB

english, 1994

44

Conformationally restricted analogues of nicotine and anabasine

Jean-Michel Vernier, Heather Holsenback, Nicholas D.P. Cosford, Jeffrey P. Whitten, Frédérique Menzaghi, Richard Reid, Tadimeti S. Rao, Aida I. Sacaan, G.Kenneth Lloyd, Carla M. Suto, Laura E. Chavez-

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 321 KB

english, 1998

45

Recent Progress in the Synthesis and Characterization of Group II Metabotropic Glutamate Receptor Allosteric Modulators

Sheffler, Douglas J., Pinkerton, Anthony B., Dahl, Russell, Markou, Athina, Cosford, Nicholas D. P.

Journal:

ACS Chemical Neuroscience

Year:

2011

Language:

english

File:

PDF, 1.29 MB

english, 2011

46

Encyclopedia of Reagents for Organic Synthesis || Copper(II) Chloride

Cosford, Nicholas D. P.

Year:

2001

Language:

english

File:

PDF, 390 KB

english, 2001

47

Aryl- and Heteroaryl-Alkyne Coupling Reactions Catalyzed by Palladium on Carbon and CuI in an Aqueous Medium

Bleicher, Leo, Cosford, Nicholas D. P.

Journal:

Year:

1995

File:

PDF, 186 KB

1995

48

Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[ 11 C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2

Zhang, Xiaofei, Kumata, Katsushi, Yamasaki, Tomoteru, Cheng, Ran, Hatori, Akiko, Ma, Longle, Zhang, Yiding, Xie, Lin, Wang, Lu, Kang, Hye Jin, Sheffler, Douglas J., Cosford, Nicholas D. P., Zhang, Min

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 1000 KB

english, 2017

49

A Practical and Efficient Synthesis of the Selective Neuronal Acetylcholine-Gated Ion Channel Agonist ( S )-(−)-5-Ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine Maleate (SIB-1508Y)

Bleicher, Leo S., Cosford, Nicholas D. P., Herbaut, Audrey, McCallum, J. Stuart, McDonald, Ian A.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 120 KB

english, 1998

50

Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist

Nicholas D.P Cosford, Leo Bleicher, Jean-Michel Vernier, Laura Chavez-Noriega, Tadimeti S Rao, Robert S Siegel, Carla Suto, Mark Washburn, G.Kenneth Lloyd, Ian A McDonald

Journal:

Pharmaceutica Acta Helvetiae

Year:

2000

Language:

english

File:

PDF, 135 KB

english, 2000

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